USS Comfort operated throughout World War II with a Navy crew and Army medical personnel. She sailed from San Pedro, on 21 June 1944 for Brisbane, Australia, and Hollandia, New Guinea. Operating from Hollandia, where a major Army hospital centre had been established to handle casualties from the Philippine operations, the hospital ship evacuated wounded from Leyte, Philippine Islands, on two voyages in October and November and then brought patients back to San Pedro, Calif., in December. Returning by way of Leyte, Comfort reached Hollandia on 6 February 1945. Following a voyage to Subic Bay and Lingayen Gulf, Luzon, for evacuees in March, the hospital ship stood by off Okinawa from 2 to 9 April, receiving wounded for evacuation to Guam.